Senior R&D Scientist - Solid Dosage Development

EVA Pharma

EVA Pharma is hiring Senior scientist to lead the design, development, optimisation, and scale-up of Fixed Dose Combination (FDC) generic products in tablet and capsule forms. The role should demonstrate deep expertise in multi-API formulation science, compatibility assessment, and dissolution development.

Main responsibilities:

Formulation Design & Optimisation

• Design and develop FDC tablet and capsule formulations combining two or more APIs

• Conduct preformulation: solubility, compatibility, polymorphism, and hygroscopicity for each API and the combination

• Select excipients and platforms IR, MR, bilayer, multi-particulate based on TPP

• Optimise formulations using QbD, DoE, and FMEA

Compatibility & Stability

• Execute drug-drug and drug-excipient compatibility and forced degradation studies

• Design and run ICH stability protocols; interpret data and propose formulation adjustments

Dissolution Development

• Develop and validate discriminatory dissolution methods for each API in the FDC

• Select biorelevant media and apparatus; investigate and resolve dissolution failures

Process Development & Scale-Up

• Develop manufacturing processes wet/dry granulation, direct compression, encapsulation suited to FDC requirements

• Define CPPs and CQAs; execute scale-up and process validation from lab to pilot to commercial

Tech Transfer

• Prepare tech transfer packages: formulation dossier, batch records, process descriptions, in-process specs

• Support on-site transfer, resolve deviations, and ensure reproducible handover to manufacturing

BE Support

• Contribute to BE protocol design and formulation rationale for generic FDC versus reference innovator

• Support interpretation of BE outcomes and propose reformulation where needed

Scientific Guidance

• Provide day-to-day technical guidance to 1 3 junior scientists

• Review data, troubleshoot failures, and maintain up-to-date knowledge of FDC science and compendial updates